Home / News & EVENTS / Blog

Common HVAC Challenges in Cleanroom Operations

Apr 23,2025 | Blog

Any questions?

We have a passion for unconventional solutions that bring your vision to life.

In cleanroom operations, the HVAC (Heating, Ventilation, and Air Conditioning) system is crucial for maintaining environmental stability. It must control not only temperature and humidity but also ensure the stability of air cleanliness, pressure differentials, and airflow direction. However, in practical operation, HVAC systems frequently face various challenges that, if not handled properly, will directly impact product quality and compliance.

 

Unstable Pressure Differentials

Strict pressure differential relationships must be maintained between different functional areas within a cleanroom, such as positive pressure to prevent contamination ingress and negative pressure to prevent contamination spread. Once the HVAC system is improperly designed or operates abnormally, it can easily lead to pressure fluctuations, affecting the isolation effectiveness of clean zones.

 

HEPA Filter Clogging or Leakage

High-Efficiency Particulate Air (HEPA) filters are the core of a cleanroom's filtration system. As operating time increases, filters gradually accumulate dust. If they are not replaced or leak-tested in a timely manner, this will lead to a decrease in airflow, reduced filtration efficiency, and even particulate leakage.

 

Substandard Air Velocity and Air Changes per Hour (ACH)

Different grades of cleanrooms have strict requirements for air velocity and air changes per hour (ACH). Decreased fan performance or insufficient system design redundancy can lead to reduced air circulation efficiency, affecting the cleanliness level.

 

Temperature and Humidity Fluctuations

Temperature and humidity within a cleanroom must be maintained within a set range, which is particularly critical in the biopharmaceutical and precision electronics industries. HVAC control system failures, sensor errors, or slow system response may cause abnormal temperature and humidity in localized areas, thereby affecting process stability.

 

High Energy Consumption and Low System Operating Efficiency

Some older HVAC systems lack energy-saving designs, such as constant air volume without on-demand adjustment, leading to high energy consumption. With increasing environmental protection requirements, how to optimize energy efficiency while ensuring clean performance has become a key concern for enterprises.

 

In summary, the stable operation of the HVAC system is essential for cleanrooms. It is recommended that enterprises regularly perform system calibration and maintenance, combined with intelligent monitoring technology, to achieve early warning management, thereby improving the reliability and energy efficiency of cleanroom operations. Wiskind cleanroom, is committed to providing the reliable cleanroom solution for  industries including pharmaceutical, semiconductor, food and hospital. Our solutions are meticulously crafted to meet strict industry standards. Our products and service cover all the aspects from design to construction like cleanroom enclosure structure, doors and windows, flooring, lighting system, HVAC systems and more.  Contact us for a quote if you have an idea of building a cleanroom for your business!


Related Products

Talk to us now!
Wiskind Cleanroom Inc.

Wiskind Cleanroom specializes in cleanroom enclosure system , ceiling system, cleanroom doors and windows and related product development, manufacturing, sales, consulting and services.

Copyright © 2025 Shandong Wiskind Clean Technology Co.,Ltd. All Rights Reserved.  Privacy PolicySitemap